The paper presents the most common toxic substances used in malicious poisoning of dogs and cats in the territory of the Republic of Serbia, mechanisms of their action, symptoms that occur in poisoned animals, antidote therapy and in the case of death, pathomorphological changes. The understanding of the mechanisms of toxic action of the most common substances used and the clinical symptoms in poisoned dogs and cats contribute to a faster diagnosis and the prompt suitable therapy application. The participation of forensic veterinarians in official procedures prior to criminal proceedings is necessary, considering its importance in the recognition and prosecution of acts defined in Article 269 of the Criminal Code (Official Gazette of RS, No. 85/2005, 88/2005 - amended, 107/2005 - amended, 72/2009, 111/2009, 121/2012, 104/2013, 108/2014, 94/2016 and 35/2019).
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