CONSEQUENCES OF ORAL INFECTION WITH CANDIDA ALBICANS ON THE HISTOARCHITECTONICS OF ORGANS IN MALE RATS

Abstract

Experiments were conducted to evaluate the immunosuppression’s effect on the development of oral candidiasis in Wistar rats. Animals were submitted to immunosuppression in order to facilitate the establishment and persistence of Candida albicans infection. Treatment with drugs (dexamethasone and tetracycline) was initiated 7 days before C. albicans inoculation and lasted until the end of the experiments, day 9 post-inoculation, but at a higher dose for dexamethasone and at a lower dose for tetracycline. The infection was done twice at a 24 hours difference. Establishment of C. albicans infection was done by oral inoculation with 0.1 ml of saline suspension containing 3.108 3,1 x 103 viable cells of C. albicans strain ATCC 10231. Tissue injury was determined by the hystological quantification of organs collected at days 3, 6 and respectively 9 of the experiment. Our results have shown that candidiasis affected organs in male rats in the following order: tongue, intestines, liver, spleen and kidney. There was a gradual evolution of the histological lesions severity in the tongue starting from the third day towards the end, but, in reverse, all the other organs affected started having regenerative healing processes at the end of the experiment.